- Date 8 Nov 2011
Domainex’s initial attention will be focused on breast and ovarian cancers. Breast cancer is the most common cancer in women. Every year it affects over a million women worldwide and is the leading cause of death for women aged 40-44. The five-year survival rate for Stage V cancer patients (advanced disease progression) is just 16%. Ovarian cancer is rarely diagnosed in its early stages and is usually quite advanced by the time diagnosis is made, resulting in poor prognoses. The five-year survival rate for all stages is only 35% to 38%.
Domainex’s TBK1/IKKe programme has already identified potent, selective and drug-like inhibitors. These inhibitors have been shown to be effective in inhibiting several cancer cell lines. Domainex’s research objective is to identify a Candidate Drug that is effective in disease models and would be orally well-absorbed by humans. The subsequent commercialization of this new drug would be undertaken in partnership with a large pharmaceutical company which has the resources to take the drug through clinical trials and to the marketplace.