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Director of Bioinformatics

  • Closing date 31 May 2024
  • Type Full-time
  • Duration Permanent
Biofidelity is a revolutionary genomic technology company dedicated to unleashing the potential of genomics to transform human health and the world we live in. Our adaptive platform technology removes the noise from genomic data, providing only the information needed to make decision making less complex, faster, and more accurate.    At Biofidelity we are proud to have built a culture of humanity, openness and high expectations. We work towards well-defined goals, with a strong belief that we can make genomics globally accessible. Our people are keen to take responsibility for their work and share both their successes and challenges.    Biofidelity’s core values are Humanity- care & compassion; respecting personal lives; humour. Openness- sharing research; experimental approach; permission to fail. High expectations- be fearless; make a difference; willingness to do what’s needed. Our core values define our company culture, they are shared values, goals, attitudes and practices that characterise Biofidelity employees.  We are looking for likeminded people to join the Biofidelity team.   Alongside a competitive salary and opportunities for career development, we offer a comprehensive benefits package including private medical & dental care, bonus, share option scheme, pension, income protection and life insurance, cycle to work scheme, season ticket loan, 26 days per year holiday allowance and free physical training sessions.   The role Biofidelity is seeking a talented and highly motivated Director of Bioinformatics to lead development of novel methods for next-generation sequencing.  The role is focused on our ENSPYRE platform, which significantly increases sensitivity whilst simultaneously decreasing sequencing requirements. The ideal candidate will lead development of the platform through to clinical validation and product launch. The ideal candidate is strategic, collaborative, adaptable and enjoys working in a dynamic environment.   Key responsibilities: ●      Provide strategic input on the positioning and differentiation of the ENSPYRE platform across the NGS market ●      To act as the company-wide subject matter expert for oncology focused applications of NGS, and guide the development of ENSPYRE to showcase the technology’s potential in this field ●      Provide strong leadership and mentorship, fostering a culture of innovation, collaboration, continuous improvement ●      To act both as an individual contributor and as the leader of the bioinformatic and wet lab development of the ENSPYRE platform for minimal residual disease detection ●      Provide day-to-day management of the team to meet key organisational objectives  ●      Support the career progression and personal development of team members, including mentorship, training opportunities, and performance feedback ●      Oversee the design, execution, and analysis of experiments ●      Work collaboratively with the commercial team to identify market needs, competitive landscape, and partnerships ●      Ensure adherence to Biofidelity’s SDLC policies, including relevant quality standards and regulatory requirements ●      Represent the company in scientific conferences, publications, and in discussions with partners ●      Stay up to date with emerging trends and technologies in bioinformatics, genomics, and oncology   Knowledge, Skills and Abilities: ●      Deep understanding of the oncology diagnostics market, applications of NGS within this market, and the technical and clinical limitations of existing solutions, particularly in early-detection and minimal residual disease (essential) ●      Understanding of the broader NGS market including both clinical diagnostics and research ●      Strong background in computational biology (essential), oncology (essential) and molecular biology (desired) ●      Scientific software development experience (essential, proficiency in one or more of Python, C, C++, or R) ●      Clear communicator, with a ‘can do’ attitude and the ability to work across the company including non-technical colleagues (essential) ●      Experience with NGS data analysis (essential) ●      Familiarity with standard software engineering tools (Jira, Git, CI/CD) (essential) ●      Understanding of mathematical modelling and statistical analysis of NGS data (essential) ●      Experience using bioinformatics workflow management systems (essential) ●      Experience in architecting and developing cloud-based solutions in Amazon Web Services (desired) ●      Experience in developing molecular biology workflows (desired) ●      Knowledge of relational databases such as MySQL and PostgreSQL for managing and querying large datasets (desired)   Requisite Education and Experience / Minimum Qualifications: ●      Ph.D. in Bioinformatics, Computational Biology, Genomics, or a related field (essential) ●      5+ years industry experience (essential) ●      Proven track record of leadership in bioinformatics with expertise in NGS data analysis, particularly in oncology applications (essential) ●      Strong understanding of molecular diagnostic technologies, commercialization strategies, and product positioning (desired) ●      Demonstrated experience in leading and developing multidisciplinary teams (essential) ●      Excellent communication, interpersonal, and stakeholder management skills (essential)

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