Lead Protein Engineer

  • Closing date 31 Dec 2018
  • Type Full-time
  • Duration Permanent

Nuclera is a next-generation DNA synthesis company creating solutions for the synthetic biology, enzyme engineering, and pharmaceutical industries. Our enzyme-mediated DNA synthesis platform will enable the rapid and cost-effective production of highly accurate, ultralong DNA products. We aim to be the key provider of long length variant DNA and genome libraries for protein, biological pathway, and ultimately genome-scale engineering.

We are seeking a lead protein engineer with significant experience in biomolecule engineering. You will join the growing team developing our enzymatic DNA synthesis technology, based in the Cambridge Science Park. To thrive in this role you should be comfortable working in a fast-paced environment, willing to take on responsibility, and excited to engage with the team to solve important challenges.

We are looking for a highly driven individual to:

  • Lead internal protein engineering efforts
  • Play a key role in driving forwards the biochemical aspects of Nuclera's technology
  • Interface with external synthetic biology vendors
  • Undertake rigorous QC analysis of generated proteins

To meet these challenges, the candidate will need to:

  • Hold a PhD in a relevant field with greater than 5 years academic or industrial experience
  • Have significant experience generating diverse DNA libraries for processing with high-throughput automation
  • Be familiar with analytical and biophysical techniques, such as SDS-PAGE, DLS, and thermal melts
  • Efficiently perform molecular biology tasks, such as cloning
  • Work closely with a multi-disciplinary scientific team

Experience/knowledge in the following areas would be advantageous:

  • Engineering of polymerases and other nucleic acid manipulating enzymes
  • High-throughput molecular biology automation equipment
  • Protein bioinformatics

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